In scrupulosity, a person's obsessions focus on moral or religious fears, such as the fear of being an evil person or the fear of divine retribution for sin. Although it can affect nonreligious people, it is usually related to religious beliefs. In the strict sense, not all obsessive–compulsive behaviors related to religion are instances of scrupulosity: strictly speaking, for example, scrupulosity is not present in people who repeat religious requirements merely to be sure that they were done properly.

Scrupulosity is characterized by pathological guilt about moral or religious issues. It is personally distressing, objectively dysfunctional, and often accompanied by significant impairment in social functioning. It is typically conceptualized as a moral or religious form of obsessive–compulsive disorder (OCD), although this categorization is empirically disputable.

The term is derived from the Latin "scrupulum", a sharp stone, implying a stabbing pain on the conscience. Scrupulosity was formerly called "scruples" in religious contexts, but the word "scruples" now commonly refers to a troubling of the conscience rather than to the disorder.

As a personality trait, scrupulosity is a recognized diagnostic criterion for obsessive–compulsive personality disorder. It is sometimes called "scrupulousness", but that word properly applies to the positive trait of having scruples.