Individuals with exploding head syndrome hear or experience loud imagined noises as they are falling asleep or waking up, have a strong, often frightened emotional reaction to the sound, and do not report significant pain; around 10% of people also experience visual disturbances like perceiving visual static, lightning, or flashes of light. Some people may also experience heat, strange feelings in their torso, or a feeling of electrical tinglings that ascends to the head before the auditory hallucinations occur. With the heightened arousal, people experience distress, confusion, myoclonic jerks, tachycardia, sweating, and the sensation that felt as if they had stopped breathing and had to make a deliberate effort to breathe again.

The pattern of the auditory hallucinations is variable. Some people report having a total of two or four attacks followed by a prolonged or total remission, having attacks over the course of a few weeks or months before the attacks spontaneously disappear, or the attacks may even recur irregularly every few days, weeks, or months for much of a lifetime.

Some individuals believe that EHS episodes are not natural events, but are the effects of directed energy weapons which create an auditory effect. Thus, EHS has been worked into conspiracy theories, but there is no scientific evidence that EHS has non-natural origins.

Exploding head syndrome is classified as a parasomnia and a sleep-related dissociative disorder by the 2005 International Classification of Sleep Disorders and is an unusual type of auditory hallucination in that it occurs in people who are not fully awake.

There are no specific symptoms associated with claims of EHS and reported symptoms range widely between individuals. They include headache, fatigue, stress, sleep disturbances, skin prickling, burning sensations and rashes, pain and ache in muscles and many other health problems. In severe cases such symptoms can be a real and sometimes disabling problem for the affected person, causing psychological distress. There is no scientific basis to link such symptoms to electromagnetic field exposure.

The prevalence of some reported symptoms is geographically or culturally dependent and does not imply "a causal relationship between symptoms and attributed exposure". Many such reported symptoms overlap with other syndromes known as symptom-based conditions, functional somatic syndromes, and IEI (idiopathic environmental intolerance).

Those reporting electromagnetic hypersensitivity will usually describe different levels of susceptibility to electric fields, magnetic fields, and various frequencies of electromagnetic waves. Devices implicated include fluorescent and low-energy lights, mobile, cordless/portable phones, and WiFi. A 2001 survey found that people self-diagnosing as EHS related their symptoms most frequently to mobile phone base stations (74%), followed by mobile phones (36%), cordless phones (29%), and power lines (27%). Surveys of electromagnetic hypersensitivity sufferers have not been able to find any consistent pattern to these symptoms.

Electromagnetic hypersensitivity (EHS) is a claimed sensitivity to electromagnetic fields, to which negative symptoms are attributed. EHS has no scientific basis and is not a recognised medical diagnosis. Claims are characterized by a "variety of non-specific symptoms, which afflicted individuals attribute to exposure to electromagnetic fields".

Those who are self-described with EHS report adverse reactions to electromagnetic fields at intensities well below the maximum levels permitted by international radiation safety standards. The majority of provocation trials to date have found that such claimants are unable to distinguish between exposure and non-exposure to electromagnetic fields. A systematic review in 2005 showed no convincing scientific evidence for symptoms being caused by electromagnetic fields. Since then, several double-blind experiments have shown that people who report electromagnetic hypersensitivity are unable to detect the presence of electromagnetic fields and are as likely to report ill health following a sham exposure as they are following exposure to genuine electromagnetic fields, suggesting the cause in these cases to be the nocebo effect.

A 2005 review by the UK Health Protection Agency and a 2006 systematic review each evaluated the evidence for various medical, psychological, behavioral, and alternative treatments for EHS and each found that the evidence-base was limited and not generalizable, but that the best evidence favored cognitive behavioural therapy. As of 2005, WHO recommended that people presenting with claims of EHS be evaluated to determine if they have a medical condition that may be causing the symptoms the person is attributing to EHS, that they have a psychological evaluation, and that the person's environment be evaluated for issues like air or noise pollution that may be causing problems.

Some people who feel they are sensitive to electromagnetic fields may seek to reduce their exposure or use alternative medicine. Government agencies have enforced false advertising claims against companies selling devices to shield against EM radiation.