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Deep Learning Technology: Sebastian Arnold, Betty van Aken, Paul Grundmann, Felix A. Gers and Alexander Löser. Learning Contextualized Document Representations for Healthcare Answer Retrieval. The Web Conference 2020 (WWW'20)
Funded by The Federal Ministry for Economic Affairs and Energy; Grant: 01MD19013D, Smart-MD Project, Digital Technologies
The Lance Armstrong doping case was a doping investigation that led to American former professional road racing cyclist Lance Armstrong being stripped of his seven Tour de France titles and his eventual admission to the doping.
Doping in Russian sports has a systemic nature. Russia has had 51 Olympic medals stripped for doping violations – the most of any country, four times the number of the runner-up, and more than a third of the global total. From 2011 to 2015, more than a thousand Russian competitors in various sports, including summer, winter, and Paralympic sports, benefited from a cover-up.
For much of the second phase of his career, Cyclist Lance Armstrong faced constant allegations of doping. Armstrong consistently denied allegations of doping until a partial confession during a broadcast interview with Oprah Winfrey in January 2013.
The 2007 Tour de France was affected by a series of scandals and speculations related to doping. By the end of the Tour, two cyclists were dismissed for failing tests and the wearer of the yellow jersey was voluntarily retired by his team for lying about his whereabouts and missing doping tests. A fourth rider was confirmed to having used doping while in a training session prior to the 2007 Tour and a fifth rider failed tests late in the race, with his result being officially announced just after the end of the Tour. During the competition, two teams were asked to withdraw after at least one member was found to have doped.
The events generated criticism and a general distrustful attitude toward the sport of professional cycling from media and public opinion. The doping allegations also resulted in several team sponsors threatening to retire their support if events advanced further. Some media such as German TV channels ARD and ZDF left the Tour once the first scandals broke. Following the Tour's conclusion, the sport's governing bodies spoke out about ways to combat the prevalence of doping in cycling and key team sponsors elected to withdraw their support due to the reputational damage caused by the scandals. The 2007 Tour de France has been referred to as one of the most controversial Tours. After the end of the Tour, "The Times" of London ranked it 4th in its list of the top 50 sporting scandals.
Cheating at the Paralympic Games has caused scandals that have significantly changed the way in which the International Paralympic Committee (IPC) manages the events.
Testing for performance-enhancing drugs has become increasingly strict and more widespread throughout the Games, with powerlifting seeing the most positive results. Competitors without disabilities have also competed in some Paralympic Games, with the Spanish entry in the intellectually disabled basketball tournament at the 2000 Summer Paralympics being the most controversial.
There have been allegations of doping in the Tour de France since the race began in 1903. Early Tour riders consumed alcohol and used ether, among other substances, as a means of dulling the pain of competing in endurance cycling. Riders began using substances as a means of increasing performance rather than dulling the senses, and organizing bodies such as the "Tour" and the International Cycling Union (UCI), as well as government bodies, enacted policies to combat the practice.
Use of performance-enhancing drugs in cycling predates the Tour de France. Cycling, having been from the start a sport of extremes, whether of speed by being paced by tandems, motorcycles and even cars, or of distance, the suffering involved encouraged the means to alleviate it. Not until after World War II were sporting or even particularly health issues raised. Those came shortly before the death of Tom Simpson in the Tour de France of 1967. Max Novich referred to the Tour de France in a 1973 issue of "New York State Journal of Medicine" as "a cycling nightmare". In the eyes of a 1998 German observer:
The Lamaze technique, also known as the psychoprophylactic method or simply Lamaze, started as a prepared childbirth technique popularized in the 1950s by French obstetrician Dr. Fernand Lamaze based on his observations in the Soviet Union as an alternative to the use of medical intervention during childbirth. Today, Lamaze has become a popular way to get information about pregnancy, birth, and parenting through Lamaze International.
The stated goal of Lamaze is to increase a mother's confidence in her ability to give birth; classes help pregnant women understand how to cope with pain in ways that both facilitate labor and promote comfort, including relaxation techniques, movement and massage.
The International Convention against Doping in Sport is a multilateral UNESCO treaty by which states agree to adopt national measures to prevent and eliminate drug doping in sport.
Anti-Chinese sentiment, Sinophobia (from Late Latin "Sinae" "China" and Greek φόβος, "phobos", "fear"), or Chinophobia is a sentiment against China, its people, overseas Chinese, or Chinese culture. It often targets Chinese minorities living outside of China and is complicated by the dilemma of immigration, development of national identity in neighbouring countries, disparity of wealth, the fall of the past central tribute system and majority-minority relations. Its opposite is Sinophilia. Factors contributing to sinophobia include disapproval of the Chinese government, historical grievances, fear of economic competition, and racism. Sinophobia also stems from older ethnic tensions, such as those related to Japanese nationalism, Korean nationalism, Indian nationalism and Vietnamese nationalism.
In competitive sports, doping is the use of banned athletic performance-enhancing drugs by athletic competitors. The term "doping" is widely used by organizations that regulate sporting competitions. The use of drugs to enhance performance is considered unethical, and therefore prohibited, by most international sports organizations, including the International Olympic Committee. Furthermore, athletes (or athletic programs) taking explicit measures to evade detection exacerbates the ethical violation with overt deception and cheating.
Historically speaking, the origins of doping in sports go back to the very creation of sport itself. From ancient usage of substances in chariot racing to more recent controversies in baseball and cycling, popular views among athletes have varied widely from country to country over the years. The general trend among authorities and sporting organizations over the past several decades has been to strictly regulate the use of drugs in sport. The reasons for the ban are mainly the health risks of performance-enhancing drugs, the equality of opportunity for athletes, and the exemplary effect of drug-free sport for the public. Anti-doping authorities state that using performance-enhancing drugs goes against the "spirit of sport".
Xenophobia is the fear and distrust of that which is perceived to be foreign or strange. Xenophobia can manifest itself in many ways involving the relations and perceptions of an ingroup towards an outgroup, including a fear of losing identity, suspicion of its activities, aggression, and desire to eliminate its presence to secure a presumed purity. Xenophobia is a political term and not a recognized medical phobia.
Xenophobia can also be exhibited in the form of an "uncritical exaltation of another culture" in which a culture is ascribed "an unreal, stereotyped and exotic quality". The terms xenophobia and racism are sometimes confused and used interchangeably because people who share a national origin may also belong to the same race. Due to this, xenophobia is usually distinguished by opposition to foreign culture.
Dr. Lamaze was influenced by childbirth practices in the Soviet Union, which involved breathing and relaxation techniques under the supervision of a ""monitrice"", or midwife. The Lamaze method gained popularity in the United States after Marjorie Karmel wrote about her experiences in her 1959 book "Thank You, Dr. Lamaze", and with the formation of the American Society for Psycho prophylaxis in Obstetrics (ASPO Lamaze). Currently Lamaze International, founded by Karmel and Elisabeth Bing, is the premier childbirth education certifying organization in the world.
Modern Lamaze childbirth classes teach expectant mothers many ways to work with the labor process to reduce the pain associated with childbirth and promote normal (physiological) birth including the first moments after birth. Techniques include allowing labour to begin on its own, movement and positions, massage, aromatherapy, hot and cold packs, breathing techniques, the use of a "birth ball" (yoga or exercise ball), spontaneous pushing, upright positions for labour and birth, breastfeeding techniques, and keeping mother and baby together after childbirth. Each class has a specific curriculum that includes learning about common medical interventions and pain relief such as an epidural in an evidence based, non-biased manner.
The glass delusion is an external manifestation of a psychiatric disorder recorded in Europe mainly in the late Middle Ages and early modern period (15th to 17th centuries). People feared that they were made of glass "and therefore likely to shatter into pieces". One famous early sufferer was King Charles VI of France who refused to allow people to touch him, and wore reinforced clothing to protect himself from accidental "shattering".
Side effects in women include:
- hair loss
- male pattern baldness
- hypertrophy of the clitoris
- increased sex drive
- irregularities of the menstrual cycle
- development of masculine facial traits
- increased coarseness of the skin
- premature closure of the epiphysis
In countries where the use of these drugs is controlled, there is often a black market trade of smuggled or counterfeit drugs. The quality of these drugs may be poor and can cause health risks. In countries where anabolic steroids are strictly regulated, some have called for a regulatory relief. Steroids are available over-the-counter in some countries such as Thailand and Mexico.
Gene doping is the hypothetical non-therapeutic use of gene therapy by athletes in order to improve their performance in those sporting events which prohibit such applications of genetic modification technology, and for reasons other than the treatment of disease. , there is no evidence that gene doping has been used for athletic performance-enhancement in any sporting events. Gene doping would involve the use of gene transfer to increase or decrease gene expression and protein biosynthesis of a specific human protein; this could be done by directly injecting the gene carrier into the person, or by taking cells from the person, transfecting the cells, and administering the cells back to the person.
The historical development of interest in gene doping by athletes and concern about the risks of gene doping and how to detect it moved in parallel with the development of the field of gene therapy, especially with the publication in 1998 of work on a transgenic mouse overexpressing insulin-like growth factor 1 that was much stronger than normal mice, even in old age, preclinical studies published in 2002 of a way to deliver erythropoietin (EPO) via gene therapy, and publication in 2004 of the creation of a "marathon mouse" with much greater endurance than normal mice, created by delivering the gene expressing PPAR gamma to the mice. The scientists generating these publications were all contacted directly by athletes and coaches seeking access to the technology. The public became aware of that activity in 2006 when such efforts were part of the evidence presented in the trial of a German coach.
Scientists themselves, as well as bodies including the World Anti-Doping Agency (WADA), the International Olympic Committee, and the American Association for the Advancement of Science, started discussing the risk of gene doping in 2001, and by 2003 WADA had added gene doping to the list of banned doping practices, and shortly thereafter began funding research on methods to detect gene doping.
Genetic enhancement includes manipulation of genes or gene transfer by healthy athletes for the purpose of physically improving their performance. Genetic enhancement includes gene doping and has potential for abuse among athletes, all while opening the door to political and ethical controversy.
States that agree to the Convention align their domestic rules with the World Anti-Doping Code, which is promulgated by the World Anti-Doping Agency. This includes facilitating doping controls and supporting national testing programmes; encouraging the establishment of "best practice" in the labelling, marketing, and distribution of products that might contain prohibited substances; withholding financial support from those who engage in or support doping; taking measures against manufacturing and trafficking; encouraging the establishment of codes of conduct for professions relating to sport and anti-doping; and funding education and research on drugs in sport.
A self-inflicted wound (SIW), is the act of harming oneself where there are no underlying psychological problems related to the self-injury, but where the injurer wanted to take advantage of being injured.
In medical contexts, rhotacism () is the inability to pronounce or difficulty in pronouncing the sound "r." Many speech pathologists call this problem "de"-rhotacization, because the sounds lose their rhotic quality rather than becoming rhotic.
Abortion doping refers to the rumoured practice of purposely inducing pregnancy for athletic performance-enhancing benefits, then aborting the pregnancy.
The symptoms of jet lag can be quite varied, depending on the amount of time zone alteration, time of day, and individual differences. Sleep disturbance occurs, with poor sleep upon arrival and/or sleep disruptions such as trouble falling asleep (when flying east), early awakening (when flying west), and trouble remaining asleep. Cognitive effects include poorer performance on mental tasks and concentration; increased fatigue, headaches, and irritability; and problems with digestion, including indigestion, changes in the frequency of defecation and consistency of faeces, and reduced interest in and enjoyment of food. The symptoms are caused by a circadian rhythm that is out of sync with the day-night cycle of the destination, as well as the possibility of internal desynchronisation. Jet lag has been measured with simple analogue scales, but a study has shown that these are relatively blunt for assessing all the problems associated with jet lag. The Liverpool Jet Lag Questionnaire was developed to measure all the symptoms of jet lag at several times of day, and this dedicated measurement tool has been used to assess jet lag in athletes.
Jet lag may require a change of three time zones or more to occur, though some individuals can be affected by as little as a single time zone or the single-hour shift to or from daylight saving time. Symptoms and consequences of jet lag can be a significant concern for athletes travelling east or west to competitions, as performance is often dependent on a combination of physical and mental characteristics that are impacted by jet lag.
Victor Khrisanfovich Kandinsky () (1849, Byankino, Siberia - 1889) was a Russian physician, and was 2nd cousin to famed artist Wassily Kandinsky. He was born in Siberia into a large family of extremely wealthy businessmen.
In 1877 as a military physician in the Balkans during the Russo-Turkish War, he began experiencing mood swings and hallucinations. Kandinsky performed self-diagnosis, and he referred to his mental condition as "Primäre Verrücktheit" (primary paranoid psychosis) which has been anachronistically translated into modern terms as a "schizophrenic-like state". In 1885 Kandinsky published a book written in German on "pseudohallucinations" in which he describes and details hallucinations largely based on his personal experiences. In September 1889, feeling that his psychotic symptoms were returning, he took his own life by taking an overdose of morphine. He died as a patient in the institution he had formerly run as the medical superintendent, the St. Nicholas Asylum in St. Petersburg.
In a monograph published posthumously in 1890, Kandinsky described a condition which involved being alienated from one's personal mental processes, combined with delusions of being physically and mentally influenced by external forces. The syndrome he described is now known as Kandinsky-Clérambault syndrome, named along with French psychiatrist Gaëtan Gatian de Clérambault. The syndrome also known as "syndrome of psychic automatism".
Concentration of the glass delusion among the wealthy and educated classes allowed modern scholars to associate it with a wider and better described disorder of scholar's melancholy.
Travel fatigue is general fatigue, disorientation, and headache caused by a disruption in routine, time spent in a cramped space with little chance to move around, a low-oxygen environment, and dehydration caused by dry air and limited food and drink. It does not necessarily involve the shift in circadian rhythms that cause jet lag. Travel fatigue can occur without crossing time zones, and it often disappears after a single day accompanied by a night of good quality sleep.
Anti-Catholicism (also referred to as Catholicophobia or Catholico- phobia) is hostility towards Catholics or opposition to the Catholic Church, its clergy and its adherents.
After the Protestant Reformation and until at least the late 20th Century, the majority of Protestant states (especially the United Kingdom and the United States) made anti-Catholicism and opposition to the Pope and Catholic rituals major political themes, with anti-Catholic sentiment at times leading to violence and religious discrimination against Catholic individuals (often derogatorily referred to in Anglophone Protestant countries as "papists" or "Romanists"). Historically, Catholics in Protestant countries were frequently suspected of conspiring against the state in furtherance of papal interests or to establish a political hegemony under the "Papacy", with Protestants sometimes questioning Catholic individuals' loyalty to the state and suspecting Catholics of ultimately maintaining loyalty to the Vatican rather than maintaining loyalty to their domiciled countries. In majority Protestant countries with large scale immigration, such as the United States and Australia, suspicion or discrimination of Catholic immigrants often overlapped or conflated with nativism, xenophobia, and ethnocentric or racist sentiments (i.e. anti-Italianism, anti-Irish sentiment, Hispanophobia, anti-Quebec sentiment, anti-Polish sentiment).
In the Early modern period, in the face of rising secular powers in Europe, the Catholic Church struggled to maintain its traditional religious and political role in primarily Catholic nations. As a result of these struggles, there arose in some majority Catholic countries a hostile attitude towards the considerable political, social, spiritual and religious power of the Pope and the clergy in the form of anti-clericalism.
A 2016 review found that about 120 DNA polymorphisms had been identified in the literature related to some aspect of athletic performance, 77 related to endurance and 43 related to power. 11 had been replicated in three or more studies and six were identified in genome-wide association studies, but 29 had not been replicated in at least one study.
The 11 replicated markers were:
- Endurance:
- ACE Alu I/D (rs4646994) (Called ACE I)
- ACTN3 577X
- PPARA rs4253778 G,
- PPARGC1A Gly482;
- power/strength markers:
- ACE Alu I/D (rs4646994) (called ACE D)
- ACTN3 Arg577
- AMPD1 Gln12
- HIF1A 582Ser
- MTHFR rs1801131 C
- NOS3 rs2070744 T
- PPARG 12Ala
The six GWAS markers were:
- CREM rs1531550 A,
- DMD rs939787 T
- GALNT13 rs10196189 G
- NFIA-AS1 rs1572312 C,
- RBFOX1 rs7191721 G
- TSHR rs7144481 C