Heart-hand syndrome type 1 is more commonly known as Holt–Oram syndrome. Is the most prevalent form of heart-hand syndrome.

It is an autosomal dominant disorder that affects bones in the arms and hands (the upper limbs) and may also cause heart problems. The syndrome includes an absent radial bone in the arms, an atrial septal defect, and a first degree heart block.

Heart-hand syndromes are a group of rare diseases that manifest with both heart and limb deformities.

, known heart-hand syndromes include Holt–Oram syndrome, Berk–Tabatznik syndrome, heart-hand syndrome type 3, brachydactyly-long thumb syndrome, patent ductus arteriosus-bicuspid aortic valve syndrome and heart hand syndrome, Slovenian type.

Common symptoms include:

- tachycardia (a heart rate exceeding the normal resting rate)

- respiratory problems

- dyspnea (shortness of breath)

- continuous "machine-like" (also described as "rolling-thunder" and "to-and-fro") heart murmur (usually from aorta to pulmonary artery, with higher flow during systole and lower flow during diastole)

- cardiomegaly (enlarged heart, reflecting ventricular dilation and volume overload)

- left subclavicular thrill

- bounding pulse

- widened pulse pressure

- increased cardiac output

- increased systolic pressure

- poor growth

- differential cyanosis, i.e. cyanosis of the lower extremities but not of the upper body.

Patients typically present in good health, with normal respirations and heart rate. If the PDA is moderate or large, widened pulse pressure and bounding peripheral pulses are frequently present, reflecting increased left ventricular stroke volume and diastolic run-off of blood into the (initially lower-resistance) pulmonary vascular bed. Prominent suprasternal and carotid pulsations may be noted secondary to increased left ventricular stroke volume.

Patent ductus arteriosus (PDA) is a condition wherein the ductus arteriosus fails to close after birth.

Early symptoms are uncommon, but in the first year of life include increased 'work of breathing' and poor weight gain. An uncorrected PDA may lead to congestive heart failure with increasing age.

The ductus arteriosus is a fetal blood vessel that closes soon after birth. In a PDA, the vessel does not close and remains "patent" (open), resulting in irregular transmission of blood between the aorta and the pulmonary artery. PDA is common in newborns with persistent respiratory problems such as hypoxia, and has a high occurrence in premature newborns. Premature newborns are more likely to be hypoxic and have PDA due to underdevelopment of the heart and lungs.

A PDA allows a portion of the oxygenated blood from the left heart to flow back to the lungs by flowing from the aorta (which has higher pressure) to the pulmonary artery. If this shunt is substantial, the neonate becomes short of breath: the additional fluid returning to the lungs increases lung pressure, which in turn increases the energy required to inflate the lungs. This uses more calories than normal and often interferes with feeding in infancy. This condition, as a constellation of findings, is called congestive heart failure.

In some congenital heart defects (such as in transposition of the great vessels) a PDA may need to remain open, as it is the only way that oxygenated blood can mix with deoxygenated blood. In these cases, prostaglandins are used to keep the DA open until surgical correction of the heart defect is completed.

Word salad may describe a symptom of neurological or psychiatric conditions in which a person attempts to communicate an idea, but words and phrases that may appear to be random and unrelated come out in an incoherent sequence instead. Often, the person is unaware that he or she did not make sense. It appears in people with dementia and schizophrenia, as well as after anoxic brain injury. Clang associations are especially characteristic of mania, as seen in bipolar disorder, as a somewhat more severe variation of flight of ideas. In extreme mania, the patient's speech may become incoherent, with associations markedly loosened, thus presenting as a veritable word salad.

It may be present as:

- Clanging, a speech pattern that follows rhyming and other sound associations rather than meaning

- Graphorrhea, a written version of word salad that is more rarely seen than logorrhea in people with schizophrenia.

- Logorrhea, a mental condition characterized by excessive talking (incoherent and compulsive)

- Receptive aphasia

- Schizophasia, a mental condition characterized by incoherent babbling (compulsive or intentional, but nonsensical)

Word salad can be generated by a computer program for entertainment purposes by inserting randomly chosen words of the same type (nouns, adjectives, etc.) into template sentences with missing words, a game similar to Mad Libs. The video game company Maxis, in their seminal SimCity 2000, used this technique to create an in-game "newspaper" for entertainment; the columns were composed by taking a vague story-structure, and using randomization, inserted various nouns, adjectives, and verbs to generate seemingly unique stories.

Another way of generating meaningless text is mojibake, also called "Buchstabensalat" ("letter salad") in German, in which an assortment of seemingly random text is generated through character encoding incompatibility in which one set of characters are replaced by another, though the effect is more effective in languages where each character represents a word, such as Chinese, than a letter.

More serious attempts to produce nonsense automatically stem from Claude Shannon's seminal paper "A Mathematical Theory of Communication" from 1948

where progressively more convincing nonsense is generated first by choosing letters and spaces randomly, then according to the frequency with which each character appears in some sample of text, then respecting the likelihood that the chosen letter appears after the preceding one or two in the sample text, and then applying similar techniques to whole words. Its most convincing nonsense is generated by second-order word approximation, in which words are chosen by a random function weighted to the likeliness that each word follows the preceding one in normal text:

THE HEAD AND IN FRONTAL ATTACK ON AN ENGLISH WRITER THAT THE CHAR-

ACTER OF THIS POINT IS THEREFORE ANOTHER METHOD FOR THE LETTERS THAT

THE TIME OF WHO EVER TOLD THE PROBLEM FOR AN UNEXPECTED.

Markov chains can be used to generate random but somewhat human-looking sentences. This is used in some chat-bots, especially on IRC-networks.

Nonsensical phrasing can also be generated for more malicious reasons, such as the Bayesian poisoning used to counter Bayesian spam filters by using a string of words which have a high probability of being collocated in English, but with no concern for whether the sentence makes sense grammatically or logically.

There are some common witnesses of evil eye are eyes with different colors especially green or blue its common but can be considered as a curse or Badluck but most of the cases are its just the brain. The brain is very complicated and sometimes it gives information from eyes or process from the brain by the memory that are not actually at present. However it can be a curse or a message from the "Devil".

The evil eye is a curse believed to be cast by a malevolent glare, usually given to a person when they are unaware. Many cultures believe that receiving the evil eye will cause misfortune or injury. Talismans created to protect against the evil eye are also frequently called "evil eyes".

The idea expressed by the term causes many different cultures to pursue protective measures against it. The concept and its significance vary widely among different cultures, primarily in West Asia. The idea appears several times in rabbinic literature. It was a widely extended belief among many Mediterranean and Asian tribes and cultures. Charms and decorations with eye-like symbols known as nazars, which are used to repel the evil eye, are a common sight across Armenia, Albania, Tunisia, Turkey, Egypt, Iran, Iraq, Pakistan, Israel, Morocco, Greece, the Levant, Afghanistan, Syria, southern Spain, and Mexico, and have become a popular choice of souvenir with tourists.