The symptoms of autophobia vary by case. However, there are some symptoms that a multitude of people with this disease suffer from. An intense amount of apprehension and anxiety when you are alone or think about situations where you would be secluded is one of the most common indications that a person is autophobic. People with this disorder also commonly believe that there is an impending disaster waiting to occur whenever they are left alone. For this reason, autophobes go to extreme lengths to avoid being in isolation. However, people with this disease often do not need to be in "physical" isolation to feel abandoned. Autophobes will often be in a crowded area or group of people and feel as though they are completely secluded.

There has also been some connection to autophobia being diagnosed in people who also suffer from borderline personality disorders.

Below is a list of other symptoms that are sometimes associated with autophobia:

- Mental symptoms:

- Fear of fainting

- A disability to concentrate on anything other than the disease

- Fear of losing your mind

- Failure to think clearly

- Emotional symptoms:

- Stress over up-coming times and places where you may be alone

- Fear of being secluded

- Physical symptoms:

- Lightheadedness, dizziness

- Sweating

- Shaking

- Nausea

- Cold and hot flashes

- Numbness or tingling feelings

- Dry mouth

- Increased heart rate

Autophobia, also called monophobia, isolophobia, or eremophobia, is the specific phobia of isolation; a morbid fear of being egotistical, or a dread of being alone or isolated. Sufferers need not be physically alone, but just to believe that they are being ignored or unloved. Contrary to what would be implied by a literal reading of the term, "autophobia" does not describe a "fear of oneself". The disorder typically develops from and is associated with other anxiety disorders.

Autophobia can be associated with or accompanied by several other phobias such as agoraphobia, and is generally considered to be a part of the agoraphobic cluster. This means that autophobia has a lot of the same characteristics as certain anxiety disorders and hyperventilation disorders. The main concern of people with phobias in the agoraphobic cluster is getting help in case of emergency. This means people might be afraid of going out in public, being caught in a crowd, being alone, or being stranded.

Autophobia is not to be confused with agoraphobia (fear of being in public, or caught in large crowds), self-hatred, or social anxiety although it can be closely related to these things. It is its own phobia that tends to be accompanied by other anxiety disorders and phobias.

Mental and emotional symptoms of lilapsophobia include

- Obsessive thoughts

- Difficulty thinking

- Feeling of unreality or being detached

- Fear of losing control or going crazy

- Anticipatory anxiety

- Terror

- Desire to flee or hide

Physical symptoms of lilapsophobia include

- Dizziness, shaking, palpitations, lightheaded, or faint

- Shortness of breath

- Accelerated heartbeat

- Chest pain or discomfort

- Shaking

- Feeling of choking

- Sweating

- Nausea

- Numbness or tingling sensations

Many lilapsophobes also suffer autophobia, fear of being alone. Sufferers often make arrangements with people they know to help soothe the fear.

Like many phobias, lilapsophobia is caused by an unwanted experience, specifically tornadoes or hurricanes that cause injuries, destruction, or loss of loved ones to self or others they know. People who survive those storms should seek professional advice, especially to determine if a person is suffering post-traumatic stress disorder. This phobia can even be caused by learning news about tornadoes or hurricanes using the media, like television, internet, radio, or newspaper, even though they happened far away from homes.

If a person learns that someone in the family has the phobia, then that person is more likely to suffer from it.

Avoidant individuals often choose jobs of isolation so that they do not have to interact with the public regularly, due to their anxiety and fear of embarrassing themselves in front of others. Some with this disorder may fantasize about idealized, accepting, and affectionate relationships, due to their desire to belong. Individuals with the disorder tend to describe themselves as uneasy, anxious, lonely, unwanted and isolated from others. They often feel themselves unworthy of the relationships they desire, so they shame themselves from ever attempting to begin them.

People with avoidant personality disorder are preoccupied with their own shortcomings and form relationships with others only if they believe they will not be rejected. Loss and social rejection are so painful that these individuals will choose to be alone rather than risk trying to connect with others (see rejection sensitivity). They often view themselves with contempt, while showing an increased inability to identify traits within themselves that are generally considered as positive within their societies.

- Hypersensitivity to rejection and criticism

- Self-imposed social isolation

- Extreme shyness or anxiety in social situations, though the person feels a strong desire for close relationships

- Avoids physical contact because it has been associated with an unpleasant or painful stimulus

- Feelings of inadequacy

- Drastically reduced or absent self-esteem

- Self-loathing, autophobia or self-harm

- Mistrust of others or oneself; exhibits heightened self-doubt

- Emotional distancing related to intimacy

- Highly self-conscious

- Self-critical about their problems relating to others

- Heightened attachment-related anxiety, which may include a fear of abandonment

- Problems in occupational functioning

- Lonely self-perception, although others may find the relationship with them meaningful

- Feeling inferior to others

- Substance abuse and/or dependence

- In some extreme cases, agoraphobia

- Uses fantasy as a form of escapism to interrupt painful thoughts

Avoidant personality disorder (AvPD) is a Cluster C personality disorder. Those affected display a pattern of severe social anxiety, social inhibition, feelings of inadequacy and inferiority, extreme sensitivity to negative evaluation, and avoidance of social interaction despite a strong desire for intimacy. The behavior is usually noticed by early adulthood and occurs in most situations.

People with AvPD often consider themselves to be socially inept or personally unappealing and avoid social interaction for fear of being ridiculed, humiliated, rejected or disliked. They generally avoid becoming involved with others unless they are certain they will be liked. As the name suggests, the main coping mechanism of those with avoidant personality disorder is avoidance of feared stimuli. Both childhood emotional neglect (in particular, the rejection of a child by one or both parents) and peer group rejection are associated with an increased risk for its development; however, it is possible for AvPD to occur without any notable history of abuse or neglect.

While some scientists claim the exact causes for the disorder are unknown, others found that parents of avoidant children seemed to have difficulty with their own negative emotions. Some researchers have also theorized that certain cases of AvPD may occur when individuals with innately high sensory processing sensitivity (characterized by deeper processing of physical and emotional stimuli, alongside high levels of empathy) are raised in abusive, negligent or otherwise dysfunctional environments, which inhibits their ability to form secure bonds with others.