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Angel wing, also known as airplane wing, slipped wing, crooked wing, and drooped wing, is a syndrome that affects primarily aquatic birds, such as geese and ducks, in which the last joint of the wing is twisted with the wing feathers pointing out laterally, instead of lying against the body. Males develop it more frequently than females. It has also been reported in goshawks, bustard chicks, and psittacine birds (budgerigars, macaws, and conures).
The syndrome is acquired in young birds. Due to a high-calorie diet, especially one high in proteins and/or low in vitamin D, vitamin E, and manganese, one or both carpus (wrist) joints are retarded in their development relative to the rest of the wing; for reasons unknown, if only one wing is affected, it is usually the left one. The result is a wrist which is twisted outwards and unable to perform its usual function. Angel wing symptoms include stripped remiges (flight feathers) in the wrist area, or remiges protruding from wings at odd angles. In extreme cases, the stripped feathers may resemble sickly blue straws protruding from wings. In adult birds, the disease is incurable and usually leads to an early death, as affected birds are rendered effectively or totally flightless. In young birds, wrapping the wing and binding it against the bird's flank, together with feeding the bird a more nutritionally balanced diet, can reverse the damage.
The theorized causes of angel wing are genetics, the excessive intake of carbohydrates and proteins, together with insufficient intake of vitamin E, low dietary calcium and manganese deficiency. Angel wing is occasionally observed in waterfowl residing near humans, (including domestic fowl), and the disease can sometimes be observed in areas where geese or ducks are excessively fed bread. Duck seed is an alternative for duck feeders.
Feather-plucking, sometimes termed feather-picking, feather damaging behaviour or pterotillomania, is a maladaptive, behavioural disorder commonly seen in captive birds which chew, bite or pluck their own feathers with their beak, resulting in damage to the feathers and occasionally the skin. It is especially common among Psittaciformes, with an estimated 10% of captive parrots exhibiting the disorder. The areas of the body that are mainly pecked or plucked are the more accessible regions such as the neck, chest, flank, inner thigh and ventral wing area. Contour and down feathers are generally identified as the main target, although in some cases, tail and flight feathers are affected. Although feather-plucking shares characteristics with feather pecking commonly seen in commercial poultry, the two behaviours are currently considered to be distinct as in the latter, the birds peck at and pull out the feathers of other individuals.
Feather-plucking has characteristics that are similar to trichotillomania, an impulse control disorder in humans, and hair-pulling which has been reported in mice, guinea pigs, rabbits, sheep and muskox, dogs and cats, leading to suggestions for a comparative psychology approach to alleviating these problems.
Feather-plucking is generally regarded as a multifactorial disorder, although three main aspects of bird keeping may be related to the problem: (1) cage size often restricts the bird’s movements; (2) cage design and barrenness of the environment often do not provide sufficient behavioural opportunities to meet the bird's sensitivity, intelligence and behavioural needs; and (3) solitary housing, which fails to meet the high social needs of the bird.
Diplopodia is a congenital anomaly in tetrapods that involves duplication of elements of the foot on the hind limb. It comes from the Greek roots diplo = "double" and pod = "foot". Diplopodia is often found in conjunction with other structural abnormalities and can be lethal. It is more extreme than polydactyly, the presence of extra digits.
People who are affected by Liebenberg Syndrome suffer from three main symptoms:
1. Dysplasia (improper formation) of the bony components of the elbow
2. Abnormal shape of carpal bones
3. Brachydactyly, a symptom where the fingers and toes are shorter than normal.
Liebenberg Syndrome is a rare autosomal genetic disease that involves a deletion mutation upstream of the PITX1 gene, which is one that's responsible for the body's organization, specifically in forming lower limbs. In animal studies, when this deletion was introduced to developing birds, their wing buds were noted to take on limb-like structures.
The condition was first described by Dr. F. Liebenberg in 1973 while he followed multiple generations of a South African family, but it has since been noticed in other family lineages across the world.
In medicine, heterotopia is the presence of a particular tissue type at a non-physiological site, but usually co-existing with original tissue in its correct anatomical location. In other words, it implies ectopic tissue, in addition to retention of the original tissue type. In neuropathology, for example, gray matter heterotopia is the presence of gray matter within the cerebral white matter or ventricles. Heterotopia within the brain is often divided into three groups: subependymal heterotopia, focal cortical heterotopia and band heterotopia. Another example is a Meckel's diverticulum, which may contain heterotopic gastric or pancreatic tissue.
In biology specifically, "heterotopy" refers to an altered location of trait expression. In her book "Developmental Plasticity and Evolution", Mary-Jane West Eberhard has a cover art of the sulphur crested cockatoo and comments on the back cover "Did long crest[head] feathers evolve by gradual modification of ancestral head feathers? Or are they descendants of wing feathers, developmentally transplanted onto the head". This idea sets the tone for the rest of her book which goes into depth about developmental novelties and their relation to evolution. Heterotopy is a somewhat obscure but well demonstrated example of how developmental change can lead to novel forms. The central concept is that a feature seen in one area of an organism has had its location changed in evolutionary lineages.
The affected leg usually has one foot that is in an approximately normal position. The extra foot is composed of at least some metatarsal or tarsal bones and extra digits, though it is usually not complete. The feet can be joined together, so that the limb appears to have one large foot, or the extra foot can be joined to the limb separately, usually above the level of the other foot. Diplopodia affects one or both of the hind limbs.
Fear of bats, sometimes called chiroptophobia (from the Greek χείρ - "cheir", "hand" and πτερόν - "pteron", "wing" referring to the order of the bats, and φόβος - "phobos", meaning "fear"), is a specific phobia associated with bats and to common negative stereotypes and fear of bats.
Schwabenhass (German for "hatred against Swabians") is a political slogan about aversion to the approximately 300,000 strong Swabian minority in Berlin. In 2013, the so-called "spätzlestreit" gained nationwide attention.
Contrary to a widespread misconception, only 3 species of bats feed on blood, and these species only live in Latin America. Common ignorance often leads to misidentification.
At the same time, the fear of bats may be naturally reinforced by the natural startle response experienced by an unsuspecting person, e.g., when a disturbed colony of bats dashes out of a cave. In fact, the majority of bats, specifically the microbats which make up the majority of species, are terrified of humans and see man as a potential predator; bats disturbed in their roost instinctively flee as fast as they can, with maternity colonies sometimes abandoning their babies since they are desperate to escape.
Often, people fear bats due to the possibility of contracting rabies, but only 0.5% of vampire bats carry rabies.
Heterotopy in molecular biology is the name given to the expression or placement of a gene product from what is typically found in one area to another area. It can also be further expanded to a subtle form of exaptation where a gene product used for one underlying purpose in a diverse group of organisms can re-emerge repeatedly to produce seemingly paraphyletic distributions of traits. But actual phylogenetic analysis supports a monophyletic model as does evolutionary theory. Heterotopy is used to explain this and there are so commonly cited examples.
An example is chitin a very durable structural protein used in surgical sutures as well as durable varnishes but is common to many animals especially crustaceans and insects. But is also found in the African clawed frog ("Xenopus laevis").
Wagner et al., suggest that chitin might have a microscopic function observed in cell to cell signaling and the manufacture of insect cuticle for example might represent a recurrent change in the location of expression chitin
Speculative, but however Chitin synthase is maintained in many lineages where it does not have an obvious macroscopic function.
It is thought that because so many organisms share such a profound degree of genetic and molecular similarity that shifts in the location of expression might be a regular occurrence throughout time.
Molecular analysis shows that proteins that seem to have a single specific function are instead found in many different tissue types. One example of this phenomenon is crystallin, a clear protein that makes up the lens of the eye; it is also has structural functions in the heart.
The severity and appearance of the winged scapula varies by individuals as well as the muscles and/or nerves that were affected. Pain is not seen in every case. In a study of 13 individuals with facioscapulohumeral muscular dystrophy (FSH), none of the individuals complained of pain. Fatigue, however, was a common characteristic and all had noted that there were limitations in their activities of daily life.
In most cases of winged scapula, damage to the serratus anterior muscle causes the deformation of the back. The serratus anterior muscle attaches to the medial anterior aspect of the scapula (i.e. it attaches on the side closest to the spine and runs along the side of the scapula that faces the ribcage) and normally anchors the scapula against the rib cage. When the serratus anterior contracts, upward rotation, abduction, and weak elevation of the scapula occurs, allowing the arm to be raised above the head. The long thoracic nerve innervates the serratus anterior; therefore, damage to or impingement of this nerve can result in weakening or paralysis of the muscle. If this occurs, the scapula may slip away from the rib cage, giving it the wing-like appearance on the upper back. This characteristic may particularly be seen when the affected person pushes against resistance.
The person may also have limited ability to lift their arm above their head.
In facioscapulohumeral muscular dystrophy (FSH), the winged scapula is detected during contraction of the glenohumeral joint. In this movement, the glenohumeral joint atypically and concurrently abducts and the scapula internally rotates.
The length of time between exposure to the bacteria and the appearance of symptoms is generally two to ten days, but can rarely extend to as much as 20 days. For the general population, among those exposed between 0.1 and 5% develop disease, while among those in hospital between 0.4 and 14% develop disease.
Those with Legionnaires' disease usually have fever, chills, and a cough, which may be dry or may produce sputum. Almost all with Legionnaires' experience fever, while approximately half have cough with sputum, and one third cough up blood or bloody sputum. Some also have muscle aches, headache, tiredness, loss of appetite, loss of coordination (ataxia), chest pain, or diarrhea and vomiting. Up to half of those with Legionnaires' have gastrointestinal symptoms, and almost half have neurological symptoms, including confusion and impaired cognition. "Relative bradycardia" may also be present, which is low or low-normal heart rate despite the presence of a fever.
Laboratory tests may show that kidney functions, liver functions and electrolyte levels are abnormal, which may include low sodium in the blood. Chest X-rays often show pneumonia with consolidation in the bottom portion of both lungs. It is difficult to distinguish Legionnaires' disease from other types of pneumonia by symptoms or radiologic findings alone; other tests are required for definitive diagnosis.
Persons with Pontiac fever experience fever and muscle aches without pneumonia. They generally recover in two to five days without treatment. For Pontiac fever the time between exposure and symptoms is generally a few hours to two days.
Duverney fractures can usually be seen on pelvic X-rays, but CT scans are required to fully delineate the fracture and to look for associated fractures involving the pelvic ring.
Malunion and deformity of the iliac wing can occur. Injury to the internal iliac artery can occur, leading to hypovolaemic shock. Perforation of the bowel can occur, leading to sepsis. Damage to the adjacent nerves of the lumbosacral plexus has also been described.
The syndrome consists of severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the postaxial elements of the limbs, coloboma of the eyelids, and supernumerary nipples. Additional features of the syndrome include
downward-slanting palpebral fissures, malar hypoplasia, malformed ears, and a broad nasal ridge. Other features include supernumerary vertebrae and other vertebral segmentation and rib defects, heart defects (patent ductus arteriosus, ventricular septal defect and Ostium primum atrial septal defect), lung disease from chronic infection, single umbilical artery, absence of the hemidiaphragm, hypoplasia of the femora, ossification defects of the ischium and pubis, bilobed tongue, lung hypoplasia, and renal reflux.
In addition to history and exam, it has been recommended to perform projectional radiography of the neck, chest, shoulder, and thoracic inlet to rule out structural abnormalities such as malunited or greenstick fractures. Computed tomography (CT) or magnetic resonance imaging (MRI) are rarely indicated, but may be useful to rule out certain diagnoses if suspected, such as neurofibromatosis-related injury, intervertebral disc disorder, radiculopathy, and tumors.
On 22 July 2016, a shooting occurred in the vicinity of the Olympia shopping mall in the Moosach district of Munich, Germany. Ten people, including the perpetrator, were killed and 36 others were injured. The shooting took place at a McDonald's restaurant near the shopping mall, in front of a Saturn electronics store nearby, and in the mall itself. The gunman, later identified as 18-year-old David Sonboly, died nearby from a self-inflicted gunshot wound to the head. His motive for the shooting is under investigation.
Mushroom poisoning (also known as mycetism or mycetismus) refers to harmful effects from ingestion of toxic substances present in a mushroom. These symptoms can vary from slight gastrointestinal discomfort to death. The toxins present are secondary metabolites produced by the fungus. Mushroom poisoning is usually the result of ingestion of wild mushrooms after misidentification of a toxic mushroom as an edible species. The most common reason for this misidentification is close resemblance in terms of colour and general morphology of the toxic mushrooms species with edible species.
To prevent mushroom poisoning, mushroom gatherers familiarize themselves with the mushrooms they intend to collect as well as with any similar-looking toxic species. In addition, edibility of mushrooms may depend on methods of preparation for cooking. The edibility or toxicity of some species varies with geographic location.
Symptoms of pterygium include persistent redness, inflammation, foreign body sensation, tearing, dry and itchy eyes. In advanced cases the pterygium can affect vision as it invades the cornea with the potential of obscuring the optical center of the cornea and inducing astigmatism and corneal scarring. Many patients do complain of the cosmetic appearance of the eye either with some of the symptoms above or as their major complaint.
The most prominent effect of JBS is pancreatic exocrine insufficiency. Varying degrees of decreased secretion of lipases, pancreatic juices such as trypsin, trypsinogen and others, as well as malabsorption of fats and disruptions of glucagon secretion and its response to hypoglycemia caused by insulin activity are major concerns when JBS is diagnosed. Associated with developmental errors, impaired apoptosis, and both prenatal and chronic inflammatory damage, necrosis and fibrosis of the pancreatic acini (clusters of pancreatic exocrine gland tissue, where secretion of pancreatic juice and related enzymes occurs), pancreatic exocrine insufficiency in JBS can additionally stem from congenital replacement of the acini with fatty tissue. Near total replacement of the entire pancreas with fatty tissue has also been reported. This is a progressive, sometimes fatal consequence of the disorder.
The primary malformation apparent with JBS is hypoplasia (underdevelopment) of the nasal alae, or "wing of the nose". Both hypoplasia and aplasia (partial or complete absence) of structural cartilage and tissue in this area of the nose, along with the underlying alae nasi muscle, are prevailing features of the disorder. Together, these malformations give the nose and nostrils an odd shape and appearance.
Miller syndrome is a genetic condition also known as the Genee–Wiedemann syndrome, Wildervanck–Smith syndrome, or postaxial acrofacial dystosis. The incidence of this condition is not known, but it is considered extremely rare. It is due to a mutation in the DHODH gene. Nothing is known of its pathogenesis.
New species of fungi are continuing to be discovered, with an estimated number of 800 new species registered annually. This, added to the fact that many investigations have recently reclassified some species of mushrooms from edible to poisonous has made older classifications insufficient at describing what now is known about the different species of fungi that are harmful to humans. Thus, contrary to what older registers state, it is now thought that of the approximately 100,000 known fungi species found worldwide, about 100 of them are poisonous to humans. However, by far the majority of mushroom poisonings are not fatal, and the majority of fatal poisonings are attributable to the "Amanita phalloides" mushroom.
A majority of these cases are due to mistaken identity. This is a common occurrence with "A. phalloides" in particular, due to its resemblance to the Asian paddy-straw mushroom, "Volvariella volvacea". Both are light-colored and covered with a universal veil when young.
"Amanita"s can be mistaken for other species, as well, in particular when immature. On at least one occasion they have been mistaken for "Coprinus comatus". In this case, the victim had some limited experience in identifying mushrooms, but did not take the time to correctly identify these particular mushrooms until after he began to experience symptoms of mushroom poisoning.
The author of "Mushrooms Demystified", David Arora cautions puffball-hunters to beware of "Amanita" "eggs", which are "Amanita"s still entirely encased in their universal veil. "Amanita"s at this stage are difficult to distinguish from puffballs. Foragers are encouraged to always cut the fruiting bodies of suspected puffballs in half, as this will reveal the outline of a developing "Amanita" should it be present within the structure.
A majority of mushroom poisonings in general are the result of small children, especially toddlers in the "grazing" stage, ingesting mushrooms found in the lawn. While this can happen with any mushroom, "Chlorophyllum molybdites" is often implicated due to its preference for growing in lawns. "C. molybdites" causes severe gastrointestinal upset but is not considered deadly poisonous.
A few poisonings are the result of misidentification while attempting to collect hallucinogenic mushrooms for recreational use. In 1981, one fatality and two hospitalizations occurred following consumption of "Galerina autumnalis", mistaken for a "Psilocybe" species. "Galerina" and "Psilocybe" species are both small, brown, and sticky, and can be found growing together. However, "Galerina" contains amatoxins, the same poison found in the deadly "Amanita" species. Another case reports kidney failure following ingestion of "Cortinarius orellanus", a mushroom containing orellanine.
It is natural that accidental ingestion of hallucinogenic species also occurs, but is rarely harmful when ingested in small quantities. Cases of serious toxicity have been reported in small children. "Amanita pantherina", while containing the same hallucinogens as "Amanita muscaria" (e.g., ibotenic acid and muscimol), has been more commonly associated with severe gastrointestinal upset than its better-known counterpart.
Although usually not fatal, "Omphalotus" spp., "Jack-o-lantern mushrooms," are another cause of sometimes significant toxicity. They are sometimes mistaken for chanterelles. Both are bright-orange and fruit at the same time of year, although "Omphalotus" grows on wood and has true gills rather than the veins of a "Cantharellus". They contain toxins known as illudins, which causes gastrointestinal symptoms.
Bioluminescent species are generally inedible and often mildly toxic.
"Clitocybe dealbata", which is occasionally mistaken for an oyster mushroom or other edible species contains muscarine.
Toxicities can also occur with collection of morels. Even true morels, if eaten raw, will cause gastrointestinal upset. Typically, morels are thoroughly cooked before eating. "Verpa bohemica", although referred to as "thimble morels" or "early morels" by some, have caused toxic effects in some individuals. "Gyromitra" spp., "false morels", are deadly poisonous if eaten raw. They contain a toxin called gyromitrin, which can cause neurotoxicity, gastrointestinal toxicity, and destruction of the blood cells. The Finns consume "Gyromitra esculenta" after parboiling, but this may not render the mushroom entirely safe, resulting in its being called the "fugu of the Finnish cuisine".
A more unusual toxin is coprine, a disulfiram-like compound that is harmless unless ingested within a few days of ingesting alcohol. It inhibits aldehyde dehydrogenase, an enzyme required for breaking down alcohol. Thus, the symptoms of toxicity are similar to being hung over—flushing, headache, nausea, palpitations, and, in severe cases, trouble breathing. "Coprinus" species, including "Coprinopsis atramentaria", contain coprine. "Coprinus comatus" does not, but it is best to avoid mixing alcohol with other members of this genus.
Recently, poisonings have also been associated with "Amanita smithiana". These poisonings may be due to orellanine, but the onset of symptoms occurs in 4 to 11 hours, which is much quicker than the 3 to 20 days normally associated with orellanine.
"Paxillus involutus" is also inedible when raw, but is eaten in Europe after pickling or parboiling. However, after the death of the German mycologist Dr Julius Schäffer, it was discovered that the mushroom contains a toxin that can stimulate the immune system to attack its own red blood cells. This reaction is rare, but can occur even after safely eating the mushroom for many years. Similarly, "Tricholoma equestre" was widely considered edible and good, until it was connected with rare cases of rhabdomyolysis.
In the fall of 2004, thirteen deaths were associated with consumption of "Pleurocybella porrigens" or "angel's wings". In general, these mushrooms are considered edible. All the victims died of an acute brain disorder, and all had pre-existing kidney disease. The exact cause of the toxicity was not known at this time and the deaths cannot be definitively attributed to mushroom consumption.
However, mushroom poisoning is not always due to mistaken identity. For example, the highly toxic ergot "Claviceps purpurea", which grows on rye, is sometimes ground up with rye, unnoticed, and later consumed. This can cause devastating, even fatal effects, which is called ergotism.
Cases of idiosyncratic or unusual reactions to fungi can also occur. Some are probably due to allergy, others to some other kind of sensitivity. It is not uncommon for an individual person to experience gastrointestinal upset associated with one particular mushroom species or genus.