Made by DATEXIS (Data Science and Text-based Information Systems) at Beuth University of Applied Sciences Berlin
Deep Learning Technology: Sebastian Arnold, Betty van Aken, Paul Grundmann, Felix A. Gers and Alexander Löser. Learning Contextualized Document Representations for Healthcare Answer Retrieval. The Web Conference 2020 (WWW'20)
Funded by The Federal Ministry for Economic Affairs and Energy; Grant: 01MD19013D, Smart-MD Project, Digital Technologies
The monoblast is the first stage of monocyte-macrophage maturation. The developmental stages of the monoblast are:
CFU-GM (pluripotential hemopoietic stem cell or hemocytoblast) -> monoblast -> promonocyte -> monocyte-> macrophage.
A typical monoblast is about 12 to 20 µm in diameter, has a nuclear to cytoplasm ratio of 4:1 to 3:1, and, like most myeloid blasts, has a round to oval nucleus with fine chromatin structure. One to four nucleoli are usually visible. The nucleus can be central or eccentric and it can show evidence of indentation or folding. The cytoplasm is agranular, stains moderately to lightly basophilic, and often has an intensely stained periphery and a prominent perinuclear zone.
A promonocyte (or premonocyte) is a cell arising from a monoblast and developing into a monocyte.