Panphobia, omniphobia, pantophobia, or panophobia is a vague and persistent dread of some unknown evil. Panphobia is not registered as a type of phobia in medical references.

There is no specific phobia in the DSM-5 which provides criteria for an all-encompassing fear of everything, though the defining symptom for Generalized Anxiety Disorder in this manual is "excessive anxiety and worry (apprehensive expectation) about a number of events or activities." Another very relatable state of mind is paranoia, in which one fears that unknown threats could, and most likely will, come from anyone, with distrust potentially leading to a loss of touch with reality. Delusional disorder is a more severe form of this type of disorder. Relevant academic literature may point to panphobia as merely a piece of such more complex states of mental disorder. Pseudoneurotic schizophrenia may be diagnosable in patients who, in addition to panphobia, also exhibit symptoms of "pananxiety", "panambivalence", and to a lesser extent, "chaotic sexuality". These persons differ from generalized anxiety sufferers in that they have "free-floating anxiety that rarely subsides" and are clinically diagnosable as having borderline personality disorder in the DSM-IV-TR. No significant changes related to this personality disorder were made in transitioning to the DSM-5, suggesting the diagnostic criteria are still appropriate.