Treatment of Foix–Chavany–Marie syndrome depends on the onset of symptoms and involves a multidisciplinary approach. Drugs are used in neurological recovery depending on the etiological classification of FCMS. FCMS caused by epilepsy, specifically resulting in the development of lesions in the bilateral and subcortical regions of the brain can be treated using antiepileptic drugs to reverse abnormal EEG changes and induce complete neurological recovery. In addition, a hemispherectomy can be performed to reverse neurological deficits and control the seizures. This procedure can result in a complete recovery from epileptic seizures. Physical therapy is also used to manage symptoms and improve quality of life. Classical FCMS resulting in the decline of ones ability to speak and swallow can be treated using neuromuscular electrical stimulation and traditional dysphagia therapy. Speech therapy further targeting dysphagia can strengthen oral musculature using modified feeding techniques and postures. Therapeutic feedings include practicing oral and lingual movements using ice chips. In addition, different procedures can be performed by a neurosurgeon to alleviate some symptoms.

Muteness or mutism () is an inability to speak, often caused by a speech disorder, hearing loss, or surgery. Someone who is mute may be so due to the unwillingness to speak in certain social situations.

Those who are physically mute may have problems with the parts of the human body required for human speech (the esophagus, vocal cords, lungs, mouth, or tongue, etc.).

Trauma or injury to Broca's area, located in the left inferior frontal cortex of the brain, can cause muteness.

FCMS is largely characterized by the paralysis of voluntary movement in facial, lingual, pharyngeal, and masticatory muscles, while automatic, involuntary functions of these four muscle groups remain. Automatic functions are performed by inducing involuntary reflexes, such as palatal, laryngeal, blink, and gag reflexes. Other involuntary functions that are tested include spontaneous smiling, laughter, and yawning. Patients with the disorder are able to these functions under automatic, involuntary reflex. An individual’s ability to perform these functions voluntarily are tested determined through a series of commands by the physician. Typically, individuals with the disorder are not able to perform any of these functions upon command. Dissociation between automatic and voluntary dissociation is indicated by an individuals’ ability to perform the involuntary, automatic functions, and their inability to perform the same actions, voluntary.