Medications can help regulate the apprehension and fear that come from thinking about or being exposed to a particular fearful object or situation. Antidepressant medications such as SSRIs or MAOIs may be helpful in some cases of phobia. SSRIs (antidepressants) act on serotonin, a neurotransmitter in the brain. Since serotonin impacts mood, patients may be prescribed an antidepressant. Sedatives such as benzodiazepines may also be prescribed, which can help patients relax by reducing the amount of anxiety they feel. Benzodiazepines may be useful in acute treatment of severe symptoms, but the risk-benefit ratio is against their long-term use in phobic disorders. This class of medication has recently been shown as effective if used with negative behaviors such as alcohol abuse. Despite this positive finding, benzodiazepines should be used with caution. Beta blockers are another medicinal option as they may stop the stimulating effects of adrenaline, such as sweating, increased heart rate, elevated blood pressure, tremors and the feeling of a pounding heart. By taking beta blockers before a phobic event, these symptoms are decreased, causing the event to be less frightening.

Hypnotherapy can be used alone and in conjunction with systematic desensitization to treatment phobias. Through hypnotherapy, the underlying cause of the phobia may be uncovered. The phobia may be caused by a past event that the patient does not remember, a phenomenon known as repression. The mind represses traumatic memories from the conscious mind until the person is ready to deal with them. Hypnotherapy may also eliminate the conditioned responses that occur during different situations. Patients are first placed into a hypnotic trance, an extremely relaxed state in which the unconscious can be retrieved. This state allows for patients to be open to suggestion, which helps bring about a desired change. Consciously addressing old memories helps individuals understand the event and see it in a less threatening light.

Hoplophobia is a political neologism coined by retired American military officer Jeff Cooper as a pejorative to describe an "irrational aversion to weapons." It is also used to describe the "fear of firearms" or the "fear of armed citizens." Hoplophobia is a political term and not a recognized medical phobia.

American firearms expert and retired Marine colonel Jeff Cooper coined the word in 1962 to denigrate and anger proponents of gun control by implying that their thoughts were "aberrant" and unreasoning:

I coined the term "hoplophobia" in 1962 in response to a perceived need for a word to describe a mental aberration consisting of an unreasoning terror of gadgetry, specifically, weapons. The most common manifestation of hoplophobia is the idea that instruments possess a will of their own, apart from that of their user. This is not a reasoned position, but when you point this out to a hoplophobe he is not impressed because his is an unreasonable position. To convince a man that he is not making sense is not to change his viewpoint but rather to make an enemy. Thus hoplophobia is a useful word, but as with all words, it should be used correctly.

The term was constructed from the Greek ὅπλον – "hoplon", meaning, amongst other things, "arms," and φόβος – "phobos", meaning "fear." Cooper employed the term as just another alternative to other slang terms, stating: "We read of 'gun grabbers' and 'anti-gun nuts' but these slang terms do not [explain this behavior]." Cooper's conjecture was that "the most common manifestation of hoplophobia is the idea that instruments possess a will of their own, apart from that of their user." Writing in an opinion piece, "Pittsburgh Tribune-Review" columnist Dimitri Vassilaros said that the term was intended by Cooper as tongue-in-cheek to mock those who think guns have free will.