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The Lance Armstrong doping case was a doping investigation that led to American former professional road racing cyclist Lance Armstrong being stripped of his seven Tour de France titles and his eventual admission to the doping.
The 2007 Tour de France was affected by a series of scandals and speculations related to doping. By the end of the Tour, two cyclists were dismissed for failing tests and the wearer of the yellow jersey was voluntarily retired by his team for lying about his whereabouts and missing doping tests. A fourth rider was confirmed to having used doping while in a training session prior to the 2007 Tour and a fifth rider failed tests late in the race, with his result being officially announced just after the end of the Tour. During the competition, two teams were asked to withdraw after at least one member was found to have doped.
The events generated criticism and a general distrustful attitude toward the sport of professional cycling from media and public opinion. The doping allegations also resulted in several team sponsors threatening to retire their support if events advanced further. Some media such as German TV channels ARD and ZDF left the Tour once the first scandals broke. Following the Tour's conclusion, the sport's governing bodies spoke out about ways to combat the prevalence of doping in cycling and key team sponsors elected to withdraw their support due to the reputational damage caused by the scandals. The 2007 Tour de France has been referred to as one of the most controversial Tours. After the end of the Tour, "The Times" of London ranked it 4th in its list of the top 50 sporting scandals.
For much of the second phase of his career, Cyclist Lance Armstrong faced constant allegations of doping. Armstrong consistently denied allegations of doping until a partial confession during a broadcast interview with Oprah Winfrey in January 2013.
In sports where physical strength is favored, athletes have used anabolic steroids, known for their ability to increase physical strength and muscle mass. The drug mimics the effect of testosterone and dihydrotestosterone in the body. They were developed after Eastern Bloc countries demonstrated success in weightlifting during the 1940s. At the time they were using testosterone, which carried with it negative effects, anabolic steroids were developed as a solution. The drug has been used across a wide range of sports from football and basketball to weightlifting and track and field. While not as life-threatening as the drugs used in endurance sports, anabolic steroids have negative side effects, including:
There have been allegations of doping in the Tour de France since the race began in 1903. Early Tour riders consumed alcohol and used ether, among other substances, as a means of dulling the pain of competing in endurance cycling. Riders began using substances as a means of increasing performance rather than dulling the senses, and organizing bodies such as the "Tour" and the International Cycling Union (UCI), as well as government bodies, enacted policies to combat the practice.
Use of performance-enhancing drugs in cycling predates the Tour de France. Cycling, having been from the start a sport of extremes, whether of speed by being paced by tandems, motorcycles and even cars, or of distance, the suffering involved encouraged the means to alleviate it. Not until after World War II were sporting or even particularly health issues raised. Those came shortly before the death of Tom Simpson in the Tour de France of 1967. Max Novich referred to the Tour de France in a 1973 issue of "New York State Journal of Medicine" as "a cycling nightmare". In the eyes of a 1998 German observer:
Doping in Russian sports has a systemic nature. Russia has had 51 Olympic medals stripped for doping violations – the most of any country, four times the number of the runner-up, and more than a third of the global total. From 2011 to 2015, more than a thousand Russian competitors in various sports, including summer, winter, and Paralympic sports, benefited from a cover-up.
Side effects in women include:
- hair loss
- male pattern baldness
- hypertrophy of the clitoris
- increased sex drive
- irregularities of the menstrual cycle
- development of masculine facial traits
- increased coarseness of the skin
- premature closure of the epiphysis
In countries where the use of these drugs is controlled, there is often a black market trade of smuggled or counterfeit drugs. The quality of these drugs may be poor and can cause health risks. In countries where anabolic steroids are strictly regulated, some have called for a regulatory relief. Steroids are available over-the-counter in some countries such as Thailand and Mexico.
Cheating at the Paralympic Games has caused scandals that have significantly changed the way in which the International Paralympic Committee (IPC) manages the events.
Testing for performance-enhancing drugs has become increasingly strict and more widespread throughout the Games, with powerlifting seeing the most positive results. Competitors without disabilities have also competed in some Paralympic Games, with the Spanish entry in the intellectually disabled basketball tournament at the 2000 Summer Paralympics being the most controversial.
The phenomenon known as Beatlemania originated in the United Kingdom, birthplace of the Beatles, when the band first realised enormous popularity there in 1963. Returning in 1962 from a highly formative two-year residency in Germany, the Beatles achieved a commercial breakthrough with their second UK single release, "Please Please Me" early in 1963, but gained "Superstar" status with the release of "She Loves You" later that year. There followed an almost non-stop series of concerts and tours, attended with feverish enthusiasm across the UK, for the whole of the following year. The Beatles' popularity in the UK came to exceed even that of the notable American artists Tommy Roe, Chris Montez and Roy Orbison, whose UK chart success at the time did not keep them from being overshadowed by the Beatles during their 1963 nationwide tours with the lower-billed band — an achievement previously unknown for a UK act.
With intense media interest in the Beatles during 1963, the year was also taken up with TV shows, press interviews and a weekly radio show. Despite these demands the band found time for many sessions in the recording studio, releasing two albums and four singles during the year. 1963 was also the year when Lennon's son Julian was born.
By the end of 1963, Beatlemania would begin to spread internationally. The single "I Want to Hold Your Hand" entered the US charts on 18 January 1964, selling one-and-a-half million copies in under three weeks, and the following month the Beatles made their first visit to America. The great interest in the Beatles brought about a major change in US attitudes to popular music and marked the start of the phenomenon known as the British Invasion.
States that agree to the Convention align their domestic rules with the World Anti-Doping Code, which is promulgated by the World Anti-Doping Agency. This includes facilitating doping controls and supporting national testing programmes; encouraging the establishment of "best practice" in the labelling, marketing, and distribution of products that might contain prohibited substances; withholding financial support from those who engage in or support doping; taking measures against manufacturing and trafficking; encouraging the establishment of codes of conduct for professions relating to sport and anti-doping; and funding education and research on drugs in sport.
Giacomo and Giovanni Battista Tocci were two-headed conjoined twins born in Locana, Italy between 1875 and 1877 on either July or October 4.
Chang (; ) and Eng (; ) Bunker (May 11, 1811 – January 17, 1874) were Thai-American conjoined twin brothers whose condition and birthplace became the basis for the term "Siamese twins".
Vegaphobia (or vegephobia) is the aversion to and discrimination against vegetarian and vegan people.
The International Convention against Doping in Sport is a multilateral UNESCO treaty by which states agree to adopt national measures to prevent and eliminate drug doping in sport.
Some medications that can be used for erethism are Traid and Ritalin. Methylphenidate (Ritalin) is a stimulant drug approved for therapy of attention-deficit hyperactivity disorder, postural orthostatic tachycardia syndrome and narcolepsy. It may also be prescribed for off-label use in treatment-resistant cases of lethargy, depression (mood), or neural insult.
One treatment of mercury poisoning was to admit fresh air to the patient by having him go outside daily as much as possible. Stimulants such as ammonia have also been documented to help restore pulse to a normal rhythm. For a more comprehensive reading of treatment, see Mercury poisoning, 'Treatment' section.
Their mother Maria Luigia Mezzanrosa was 19 years old; she had an easy time with the birth as they were rather small. They were delivered normally, with one head appearing first, the other head and torso second, and the pelvis and legs third. The one on their right was named Giovanni Battista, and the one on their left Giacomo. They had one umbilical cord and one placenta. Their father Giovanni Tocci had a breakdown due to the appearance of his first-born sons and was put into a lunatic asylum until he recovered a month later.
The World Anti-Doping Agency (WADA) is the main regulatory organization looking into the issue of the detection of gene doping. Both direct and indirect testing methods are being researched by the organization. Directly detecting the use of gene therapy usually requires the discovery of recombinant proteins or gene insertion vectors, while most indirect methods involve examining the athlete in an attempt to detect bodily changes or structural differences between endogenous and recombinant proteins.
Indirect methods are by nature more subjective, as it becomes very difficult to determine which anomalies are proof of gene doping, and which are simply natural, though unusual, biological properties. For example, Eero Mäntyranta, an Olympic cross country skier, had a mutation which made his body produce abnormally high amounts of red blood cells. It would be very difficult to determine whether or not Mäntyranta's red blood cell levels were due to an innate genetic advantage, or an artificial one.
Republican marriage () was a method of execution that allegedly occurred in Nantes during the Reign of Terror in Revolutionary France and "involved tying a naked man and woman together and drowning them". This was reported to have been practised during the drownings at Nantes ("noyades") that were ordered by local Jacobin representative-on-mission Jean-Baptiste Carrier between November 1793 and January 1794 in the city of Nantes. Most accounts indicate that the victims were drowned in the Loire River, although a few sources describe an alternative means of execution in which the bound couple is run through with a sword, either before, or instead of drowning.
The earliest reports of such "marriages" date from 1794, when Carrier was tried for his crimes, and they were soon cited by contemporary counter-revolutionary authors such as Louis-Marie Prudhomme and Louis Gabriel Ambroise de Bonald.
Gueules cassées (broken faces) is a French expression for facially disfigured servicemen which originated in World War I. Colonel Yves Picot is said to have coined the term when he was refused passing a checkpoint to a party.
Modulating the levels of proteins that affect psychology are also potential goals for gene doping; for example pain perception depends on endorphins and enkephalins, response to stress depends on BDNF, and an increase in synthesis of monamines could improve the mood of athletes. Preproenkephalin has been administered via gene therapy using a replication-deficient herpes simplex virus, which targets nerves, to mice with results good enough to justify a Phase I clinical trial in people with terminal cancer with uncontrolled pain. Adopting that approach for athletes would be problematic since the pain deadening would likely be permanent.
VEGF has been tested in clinical trials to increase blood flow and has been considered as a potential gene doping agent; however long term follow up of the clinical trial subjects showed poor results. The same is true of fibroblast growth factor. Glucagon-like peptide-1 increases the amount of glucose in the liver and has been administered via gene therapy to the livers of mouse models of diabetes and was shown to increase gluconeogenesis' for athletes this would make more energy available and reduce the buildup of lactic acid.
The glass delusion is an external manifestation of a psychiatric disorder recorded in Europe mainly in the late Middle Ages and early modern period (15th to 17th centuries). People feared that they were made of glass "and therefore likely to shatter into pieces". One famous early sufferer was King Charles VI of France who refused to allow people to touch him, and wore reinforced clothing to protect himself from accidental "shattering".
Trench warfare protected the bodies but left the heads exposed. Ironically, the introduction of the steel helmet in 1915 made head shots more 'survivable', but this reduction of mortality meant a mutilated life for thousands.
At the start of the war those wounded to the head were generally not considered able to survive and they would not usually be 'helped first'. This changed in the course of the war, as progress was made in medical practices like oral and maxillofacial surgery and most notably in the new field of plastic surgery. Surgeons conducted experiments with bone, cartilage and tissue transplants and the likes of Hippolyte Morestin, Harold Gillies and Léon Dufourmentel made enormous advances. Because of the experimental character of this surgery some chose to remain as they were and others could just not be helped yet. Some of the latter were helped by all kinds of new prosthetics to make them look more or less 'normal'.
Timed light exposure can be effective to help people match their circadian rhythms with the expected cycle at their destination; it requires strict adherence to timing. Light therapy is a popular method used by professional athletes to reduce jet lag. Special glasses, usually battery-driven, provide light to the eyes, thus inhibiting the production of melatonin in the brain. Timed correctly, the light may contribute to an advance or delay of the circadian phase to that which will be needed at the destination. The glasses may be used on the plane or even before users leave their departure city.
Timed melatonin administration may be effective in reducing jet lag symptoms. The benefit of using melatonin is likely to be greater for eastward flights than for westward ones because for most people it is easier to delay than to advance the circadian rhythm. There remain issues regarding the appropriate timing of melatonin use in addition to the legality of the substance in certain countries. How effective it may actually be is also questionable. For athletes, anti-doping agencies may prohibit or limit its use.
Timing of exercise and food consumption have also been suggested as remedies, though their applicability in humans and practicality for most travellers are not certain, and no firm guidelines exist. There are very little data supporting the use of diet to adjust to jet lag. While there are data supporting the use of exercise, the intensity of exercise that may be required is significant, and possibly difficult to maintain for non-athletes. These strategies may be used both before departure and after landing. Individuals may differ in their susceptibility to jet lag and in how quickly they can adjust to new sleep-wake schedules.
Short-acting sleep medications can be used to improve sleep quality and timing, and stimulating substances such as caffeine can be used to promote wakefulness, though research results on their success at adapting to jet lag are inconsistent.
For time changes of fewer than three hours, jet lag is unlikely to be a concern, and if travel is for short periods (three days or fewer) retaining a "home schedule" may be better for most people. Sleeping on the plane is only advised if it is within the destination's normal sleep time.
After each stage, four riders are tested: the overall leader, the stage winner, and two riders at random. In addition, every rider is tested before the first day's stage, normally a short time-trial. Most teams are tested in their entirety at some point during the three-week race. Additional testing may take place during the off-season, and riders are expected to keep their national cycling federation informed of their whereabouts so they can be located.
Many teams have their own drug testing programs to keep the team name clean. Teams, such as Quick-Step, have pulled riders before they compete in major competitions. Tom Boonen was pulled for cocaine before the 2008 Tour de France.
Islamophobia in Australia is a fear of Islam in Australian society; it has been associated with hostile and discriminatory practices toward Muslim individuals or communities and the exclusion of Muslims from social, cultural and political affairs.
Islamophobia and intolerance towards Muslims has existed well prior to the September 11 attacks on the United States.