In conjunction with antiemetic medications, at least one study has found that application to the Pericardium Meridian 6 acupressure point produced a positive effect in relieving postoperative nausea and vomiting. Another study found no statistically significant difference. The two general types of alternative pressure therapy are sham acupressure and the use of the P6 point. A 2015 study found that there is no significant difference between the use of either therapy in the treatment or prevention of PONV. In a review of 59 studies it was found that both therapies significantly affected the nausea aspect, but had no significant effect on vomiting.

A Cochrane review found droperidol, metoclopramide, ondansetron, tropisetron, dolasetron, dexamethasone, cyclizine, and granisetron effective for preventing PONV.

Granisetron and dexamethasone is not recommended due to the higher rate of side effects.