Necrotizing funisitis is a very severe form of funisitis in which the tissue that makes-up the umbilical cord starts to die. It is associated with congenital syphilis. It is now rare, and seen almost exclusively in the preterm infant. The majority of affected infants are stillborn, or die within a few weeks of birth.

Chorioamnionitis is a risk factor for periventricular leukomalacia and cerebral palsy.

Funisitis is inflammation of the connective tissue of the umbilical cord, which may cause abortion.

It is typically preceded by vasculitis of the umbilical artery or veins and may be the result of chorioamnionitis.

Antibiotic Treatment consists of:

- Standard: Ampicillin 2g IV every 6 hours + Gentamicin 1.5 mg/kg every 8 hours

- Alternative: Ampicillin-Sulbactam 3g IV every 5 hours, Ticarcillin-Clavulanate 3.1g IV every 4 hours, Cefoxitine 2g IV every 6 hours

- Cesarean Delivery: Ampicillin 2g IV every 6 hours + Gentamicin 1.5 mg/kg every 8 hours + Clindamycin 900 mg every 8 hours or Metronidazole 500 mg IV every 6 hours

- Penicillin-Allergy: Vancomycin 1g IV every 12 hours + Gentamicin 1.5 mg/kg every 8 hours

Completion of treatment/cure is only considered after delivery.