Dataset: 9.3K articles from Wikipedia (CC BY-SA).
More datasets: Wikipedia | CORD-19

Logo Beuth University of Applied Sciences Berlin

Made by DATEXIS (Data Science and Text-based Information Systems) at Beuth University of Applied Sciences Berlin

Deep Learning Technology: Sebastian Arnold, Betty van Aken, Paul Grundmann, Felix A. Gers and Alexander Löser. Learning Contextualized Document Representations for Healthcare Answer Retrieval. The Web Conference 2020 (WWW'20)

Funded by The Federal Ministry for Economic Affairs and Energy; Grant: 01MD19013D, Smart-MD Project, Digital Technologies

Imprint / Contact

Highlight for Query ‹2019 novel coronavirus respiratory syndrome medication

Dubin–Johnson syndrome

Abstract

Dubin–Johnson syndrome (DJS) is a rare, autosomal recessive, benign disorder that causes an isolated increase of conjugated bilirubin in the serum. Classically, the condition causes a black liver due to the deposition of a pigment similar to melanin. This condition is associated with a defect in the ability of hepatocytes to secrete conjugated bilirubin into the bile, and is similar to Rotor syndrome. It is usually asymptomatic, but may be diagnosed in early infancy based on laboratory tests. No treatment is usually needed.

Pathophysiology

The conjugated hyperbilirubinemia is a result of defective endogenous and exogenous transfer of anionic conjugates from hepatocytes into the bile. Impaired biliary excretion of bilirubin glucuronides is due to a mutation in the canalicular multiple drug-resistance protein 2 (MRP2). A darkly pigmented liver is due to polymerized epinephrine metabolites, not bilirubin.

DJS is due to a defect in the multiple drug-resistance protein 2 gene (ABCC2), located on chromosome 10. It is an autosomal recessive disease and is likely due to a loss of function mutation, since the mutation affects the cytoplasmic/binding domain.

Diagnosis

A hallmark of DJS is the unusual ratio between the byproducts of heme biosynthesis:

- Unaffected subjects have a coproporphyrin III to coproporphyrin I ratio around 3–4:1.

- In patients with DJS, this ratio is inverted, with coproporphyrin I being 3–4 times higher than coproporphyrin III. Analysis of urine porphyrins shows a normal level of coproporphyrin, but the I isomer accounts for 80% of the total (normally 25%).

In "post mortem "autopsy, the liver will have a dark pink or black appearance due to pigment accumulation.

Plentiful canalicular multiple drug-resistant protein causes bilirubin transfer to bile canaliculi. An isoform of this protein is localized to the apical hepatocyte membrane, allowing transport of glucuronide and glutathione conjugates back into the blood. High levels of gamma-glutamyl transferase (GGT) help in diagnosing pathologies involving biliary obstruction.

Diagnosis | Differentiation from Rotor Syndrome

Dubin–Johnson syndrome is similar to Rotor syndrome, but can be differentiated by:

Prognosis

Prognosis is good, and treatment of this syndrome is usually unnecessary. Most patients are asymptomatic and have normal lifespans. Some neonates present with cholestasis. Hormonal contraceptives and pregnancy may lead to overt jaundice and icterus (yellowing of the eyes and skin).

History

Dubin–Johnson syndrome was first described in 1954 by two men — Dr. Frank Johnson, a military physician and researcher at the Veterans Administration and Armed Forces Institute of Pathology in Washington, DC, and Dr. Isadore Dubin, a Canadian pathologist then working alongside him. Dr. Johnson had studied medicine at Howard University College of Medicine and faced substantial discrimination in his medical career, being turned away from active duty during the Battle of the Bulge, despite being a first lieutenant and trained physician. Later, during his internship, he was required to sleep in a tuberculosis sanitarium, as the hospital would not allow African-American physicians to live in the same residencies as white physicians, and he was prevented from rotating on several services, including general surgery. These experiences, coupled with his inherent interest in chemistry, compelled him to pursue pathology, where he ultimately met Dr. Dubin and described this syndrome for the first time.