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Familial multiple intestinal atresia


Familial multiple intestinal atresia is an inherited disorder where atresia occurs at multiple locations throughout the small and large intestines. It presents at birth and the prognosis is very poor with almost all those diagnosed with this condition dying with one month. It may be associated with combined immunodeficiency.


The underlying lesion in this condition appears to be a mutation in the TTC7A gene. This gene is located on the short arm of chromosome 2 (2p16).


In this disorder lesions can occur anywhere from the stomach to the anus. The clinical presentation depends on the location of the lesions(s).