Abstract
Chronic allograft nephropathy, abbreviated CAN and also known as sclerosing/chronic allograft nephropathy, is the leading cause of kidney transplant failure and happens month to years after the transplant.
Symptoms
CAN is characterized by a gradual decline in kidney function and, typically, accompanied by high blood pressure and hematuria.
Pathology
The histopathology is characterized by interstitial fibrosis, tubular atrophy,
fibrotic intimal thickening of arteries and glomerulosclerosis.