Abstract

B-cell prolymphocytic leukemia is a more aggressive, but still treatable, form of leukemia. The malignant B cells are larger than average. The name is commonly abbreviated B-PLL.

It can involve deletions from chromosome 11 and chromosome 13.

It has been suggested that some cases may represent a variant of mantle cell lymphoma.

It has a relatively poor prognosis.

Markers

A case has been described as CD20+, CD22+, and CD5-.

It can also be CD5+.

Another case was described as CD45+, CD19+, CD20+, CD5+, HLA-DR+, CD10-, CD23+/-, CD38+ and FMC7-.