Abstract

Chronic mucocutaneous candidiasis is an immune disorder of T cells, it is characterized by chronic infections with "Candida" that are limited to mucosal surfaces, skin, and nails. It can also be associated with other types of infections, such as human papilloma virus. An association with chromosome 2 has been identified.

Symptoms and signs

The symptoms of this condition are as follows:hyperkeratosis, skin ulcer, dyspareunia, endocardium abnormality, vision problems, hepatitis, seizures, hematuria and meningitis

Cause

In terms of the cause of chronic mucocutaneous candidiasis one finds it can be inherited either autosomal dominant or autosomal recessive There are 9 types of this condition with the first CANDF1 being located at 2p22.3-p21(cytogenetically)

Mechanism

The mechanism of the human immune system has it normally fighting in an infection(like "Candida"). Initially Th17 cells are made by the immune system, which in turn creates interleukin-17 (IL-17).Inflammation is produced and white blood cells confront infection

Chronic mucocutaneous candidiasis mutations affect IL-17 by inhibiting its pathway. This obviously in turn affects the human immune systems ability to fight infection, in total there are 9 possible types of this condition

Diagnosis

Chronic mucocutaneous candidiasis can be diagnosed in an affected individual via the following methods/tests:

Treatment

Management for an individual with chronic mucocutaneous candidiasis consists of the following(relapse occurs once treatment is ceased, in many cases):